The diagnosis of digestive cancer in a pregnant woman can be difficult, because it can be disguised by the common signs and symptoms of pregnancy.
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Gastric cancer, especially undifferentiated adenocarcinoma associated with diffuse bone metastasis accompanied by hematological disorders, is exceptionally encountered and the prognosis is very poor.
A mean survival parazi fluviatilis paraca of months was attributed to gastric cancer with bone metastasis.
Gastric cancer - causes, symptoms, diagnosis, treatment, pathology cancer ovaire familial
The management of pregnancy-associated digestive cancer represents a challenge for clinicians, requiring a multidisciplinary approach. Diagnosticul poate fi dificil, deoarece poate abdominal cancer period mascat de semnele şi simptomele specifice sarcinii. Cancerul gastric, în special adenocarcinomul nediferenţiat asociat cu metastaze osoase difuze însoţite de tulburări hematologice, este întâlnit în mod excepţional, iar prognosticul este foarte rezervat.
Un timp mediu de supravieţuire de luni a fost atribuit acestui stadiu. Managementul cancerului digestiv întâlnit în sarcină reprezintă o provocare pentru obstetrician şi necesită o abdominal cancer period abdominal cancer period.
The physiological changes occur in pregnancy during the fetal development and have the role to prepare the mother for labor and delivery 1. It is important to differentiate between normal and pathological changes, because some physiologic changes mimic the symptoms of a variety of conditions, and vice versa 1. Pregnancy involves changes in detoxifiere extremă a corpului de curățare a detoxifierii physiology, including alterations in hematologic parameters like expansion in maternal blood and plasma volume 1,2.
Thus, the result is that, the increasing in plasma volume, which is relatively larger than the increase in red cell mass, will cause a decrease in hemoglobin concentration 1,2. Generally, the predominant cause of anemia in pregnancy is iron deficiency 2.
Abdominal cancer survival rates., Abdominal cancer period
However, abdominal cancer period capacity remains normal during pregnancy 3. Hematocrit normally increases immediately after birth 3. Several types of anemia can develop during pregnancy. The most common causes include iron deficiency, folate deficiency and vitamin B12 deficiency 4. The early symptoms of anemia are usually non-specific 5. The most common symptoms of anemia are: fatigue, weakness, shortness of breath, dizziness, light headaches, shortness of breath, chest pain, and cold hands and feet 5.
Other signs may include pallor and, if the anemia is severe, tachycardia or hypotension 5,6. There are many forms of anemia, each with its own cause. Anemia can be temporary or long term, and it can range from mild to severe 6. Anemia increases the risk of preterm delivery and postpartum maternal infections 7,8. Also, anemia is the only symptom in different types of cancers occurring during pregnancy.
Materials and method We performed an observational retrospective analysis of all women diagnosed with digestive cancer during pregnancy admitted in the Department of Obstetrics and Gynecology of the Bucharest University Emergency Hospital, a tertiary center in Romania, between the 1st of January and the 31st of October The information regarding pregnancy, delivery outcomes and neonatal data was retrieved from the hospitalization sheets and the data base system of the Bucharest University Emergency Hospital.
We analyzed the types of anemia and the incidence of pregnancy-associated anemia in order to determine correlations between anemia and digestive cancers.
Pregnancy-associated digestive cancer – diagnosis and management
The most frequent pathologies associated with anemia in pregnancy were also studied. Extensive histopathological analysis and comparison between the types of cancer were also performed in order to determine the correlations between the signs and symptoms, the severity of anemia and a particular type of digestive cancer during pregnancy.
Results A total of 7, pregnant patients, with a gestational age over 20 weeks of amenorrhea, were admitted in the Department of Obstetrics and Gynecology of the Bucharest University Emergency Hospital between the 1st of January and the 31st of October The incidence of pregnancy-associated anemia was This percentage corresponds to the analysis of cases of pregnancy-associated anemia admitted in our unit during those three years.
As shown in Figure 1, the predominant conditions that lead to pregnancy-related anemia are spontaneous Many other pathologies related to anemia in pregnancy appeared with a abdominal cancer period incidence. During the three-year period, three pregnant women were diagnosed with a digestive type of cancer.
Two patients were diagnosed with gastric cancer and one of them with colon cancer. All three women were aged between 30 and 39 years old and were diagnosed with metastatic disease.
Regarding the parity, the patients were primiparous or secundiparous. At the time when the patients were diagnosed, they were between 23 and 33 weeks of gestations. The two patients with gastric cancer were diagnosed early, at 23 weeks and 24 weeks of pregnancy, while the patient with colon cancer was diagnosed at 33 weeks of amenorrhea.
None of the patients had a personal medical or family history of malignancy. The symptoms of the patients were various, but they were all correlated with a digestive condition.
The patient with colon cancer, at the abdominal cancer period of the admission in our hospital, had abdominal pain, constipation and a history of multiple hospitalizations for sub-occlusive episodes. Both patients with gastric cancer presented nausea and fatigue abdominal cancer period the moment of the hospitalization. At the physical examination, all three patients presented pale teguments and mucous membranes and they were all known with anemic syndrome from the first trimester of pregnancy, treated with iron supplements.
The blood samples revealed anemia with different levels of hemoglobin, between 6. The patient with colon cancer had the liver markers seriously modified, abdominal cancer period high levels of direct bilirubin, fibrinogen and transaminases. All three patients were tested for tumor markers: alpha-fetoprotein, carcinoembryonic antigen, CA and CA The patient with 23 weeks of pregnancy and gastric cancer and the patient with colon cancer had a positive result for CA Figure 1.
The main conditions associated to anemia in pregnancy Figure 2. Intraprocedural aspects of the esophagogastroduodenoscopy performed in the patient with 24 weeks of gestation — note a abdominal cancer period infiltrative mass located in the antral region of the stomach In both patients with gastric cancer, a bone marrow trephine biopsy was performed. It suggested metastases with a high suspicion of a primary gastric tumor, therefore an esophagogastroduodenoscopy was realized, which detected an infiltrative mass in the stomach body Figure 2.
Biopsies were taken and abdominal cancer period histopathological examination confirmed the diagnosis of gastric cancer Figure 3 and Figure 4.
All three patients underwent an abdominal ultrasound examination. The patient with colon este posibilă îndepărtarea papilomului had severe hepatomegaly, the patient with 23 weeks of pregnancy had suggestive images for hepatic metastases, adenopathy and splenomegaly, and the other patient with gastric cancer had only a mild hepatomegaly.
Regarding the obstetrical exam, the patients with viable pregnancy had no clinical features or signs of preterm labor. All three pregnancies were periodically evaluated by ultrasound. Both pregnancies developed with no issues related to the fetus, such as intrauterine growth restriction or small for gestational age. The patient with colon cancer and the one with gastric cancer and 24 weeks of pregnancy benefited from an MRI scan, which revealed, abdominal cancer period the patient with colon cancer, lesions with malignant features in the hepatic parenchyma or metastases from an extrahepatic source, while the other patient had pelvic bone metastases.
The other patient with gastric cancer benefited from an emergency CT scan, confirming the multiple metastases and the adenopathy. The evolution of the pregnant woman with 23 weeks of gestation and gastric cancer was extremely aggressive and after four days of hospitalization she suffered a cardiac arrest. For the patient with colon cancer, a caesarean section at 33 weeks of pregnancy was performed and a single live male fetus, weighting grams, with an Apgar score of 8, was extracted.
During the surgery, the right ovary appeared with malignant modifications and the histopathological exam revealed a colonic-type adenocarcinoma — Krukenberg tumor, the certain diagnosis Figure 5. After almost one month, she received chemotherapy. The patient with 24 weeks of pregnancy and gastric cancer was stabilized and after 10 days she was released and started chemotherapy. Figure 3. Microscopic photographs of well-differentiated abdominal cancer period tubular adenocarcinoma abdominal cancer period the normal gastric fundic gland with irregular branching and angulated structures invading the lamina propria.
Hematoxylin-eosin staining, ob. Signet ring gastric carcinoma. Note the monotonous proliferation of signet ring cells with intracellular mucin that displaces nucleus to side.
Moderately differentiated colonic adenocarcinoma consisting of large, atypical cells that form pseudoglandular structures of various sizes.
Hematoxylin-eosin staining, ob. Obviously, the incidence of anemia in the pregnant population is much higher, considering that only severe cases of anemia or cases associated with other pathologies are admitted. Although a rare and challenging condition, cancer during pregnancy should rapidly be identified and treated Fetal safety might be weighted for clinical decisions Anemia caused by blood loss is the most frequent in cancer during pregnancy At the outset, anemia can be mild and considered physiological in pregnancy, but the symptoms worsen as anemia worsens Gastric cancer, especially undifferentiated adenocarcinoma associated with diffuse bone metastasis accompanied by hematological disorders, is exceptionally encountered and the prognosis is very poor A mean survival time of months was attributed to gastric cancer with bone metastasis As in many other complicated cases, the multidisciplinary approach is an essential key.
The screening and diagnosis of anemia in the recenzii de la condilom trimester are of extreme importance for an easier differential diagnosis, for a better prognosis and an appropriate subsequent management. In the case of advanced, life-threatening disease as the main cause of abdominal cancer period, the medical interruption of pregnancy can be accepted and therefore an adequate complete treatment can be initiated.
Pregnancy-associated digestive cancer We presented tongue papilloma cases of digestive malignancy during pregnancy on a period of three years 15, Gastric and colon cancers during pregnancy are rare conditions. In a study that included cases of cancer during pregnancy, digestive malignancies represented almost 4. Digestive neoplasms can present signs and symptoms that can be easily confused with normal manifestations during pregnancy.
As we presented, anemia was a common sign in all three cases 15, It is important to note that anemia was present from the first trimester of pregnancy in both patients with gastric cancer, but since it is a sign that can mimic the symptoms of pregnancy, the diagnosis was established later Regarding tumor markers, their sensitivity and specificity may be lower in pregnant women CA and alpha-fetoprotein are physiologically elevated in pregnancy 19,21, However, in all our cases, tumor markers were very high and helped us making a presumptive diagnosis 15, Imaging during pregnancy, with the purpose to diagnose and stage the malignancy, should consider the risks for the fetus and the benefits for the mother Therefore, in two of our cases, the patients benefited from MRI and it was the one technique which staged the neoplasia.
Even though CT scan should be avoided due to cumulative radiation 20,24it was performed in one of our cases as an emergency exam because of her poor prognosis and the viability of the fetus. The definitive diagnosis of condiloame și răgușeală type and grading were provided by histopathological examination In both our patients with gastric cancer, an upper gastrointestinal endoscopy was performed with multiple biopsies In the patient diagnosed with colon cancer, the definitive diagnosis was established during caesarean section In abdominal cancer period study on 41 pregnant patients with colon-rectal neoplasia, 10 patients were diagnosed during acute surgery, but the others were diagnosed using endoscopy with biopsy, MRI or CT scan The oncologic management should be personalized depending, on one hand, on the type of cancer, tumor biology and staging, and on the other hand, on the viability and abdominal cancer period of the fetus Chemotherapy has teratogenic risks, but it depends on gestational age, agent and dose, and the first trimester is the highest risk period.
Because of the benefits to the mother, in many cases the assumption is warranted of risks related to chemotherapy exposure, especially during the second and third trimesters The patient with gastric cancer and viable pregnancy received chemotherapy, while the patient with colon cancer received chemotherapy after surgery. Conclusions Digestive cancer during pregnancy may present different signs and symptoms that can be masked by those of pregnancy. It is important to determine abdominal cancer period type of anemia from the first trimester of pregnancy and to make possible to have a certain diagnosis as soon as possible, because digestive cancer in women of reproductive age has a poor prognosis.
The diagnosis represents a challenge and the treatment requires a multidisciplinary team. Conflict of interests: The authors declare no conflict of interests. Bibliografie Locktich G. Clinical biochemistry of pregnancy. Crit Rev Clin Lab Sci. Rodger M, et al. Haematological problems in obstetrics. Ramsay M.
The Obstetric Hematology Manual. Cambridge: Cambridge University Press. Normal hematological changes during pregnancy and the puerperium.
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In Pavord S, Hunt B ed. Wilson M, et al. Blood pressure, the renin-aldosterone system and sex steroids throughout normal pregnancy. Am J Med. Davison JM. Renal haemodynamics and volume homeostasis in pregnancy. Tkachenko O, et al. Hormones and hemodynamics in pregnancy. Int J Endocrinol Metab. Sifakis S, Pharmakides G. Anemia in pregnancy. Ann NY Acad Sci. Xiong X, et al. Anemia during pregnancy and birth outcome: a meta-analysis.
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